Frontiers

Chemical insights into the synthetic chemistry of five-membered saturated heterocycles—a transition metal–catalyzed approach

Drug design and delivery is primarily based on the hunt for new potent drug candidates and novel synthetic techniques. Recently, saturated heterocycles have gained enormous attention in medicinal ...
C&EN

Divergent Catalysis: Catalytic Asymmetric [4+2] Cycloaddition of Palladium Enolates

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. An asymmetric decarboxylative [4+2] cycloaddition from a catalytically generated ...
PNAS

Evolutionary and functional analysis of an NRPS condensation domain integrates β-lactam, ᴅ-amino acid, and dehydroamino acid synthesis

Nonribosomal peptide synthetases (NRPSs) are large, multidomain biosynthetic enzymes involved in the assembly-line–like synthesis of numerous peptide natural products. Among these are clinically ...
C&EN

Iridium-Catalyzed Enantioselective α-Allylic Alkylation of Amides Using Vinyl Azide as Amide Enolate Surrogate

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.orglett.0c03002. Smart citations by scite.ai include citation ...