Objective Macrophage activation syndrome (MAS), a subtype of secondary haemophagocytic lymphohistiocytosis (HLH), is a rare ...

Objective No studies have investigated the incidence and correlation of scarring and dyspigmentation across all cutaneous ...

Objective Glomerular immune complex deposition plays a central role in lupus nephritis (LN), but the prognostic relevance of individual immunoglobulin components remains unclear. This study aimed to ...

Background Systemic lupus erythematosus (SLE) is about 10 times more common among women than men. This sex bias was previously attributed to sex hormones. However, while sex hormones are abnormal in ...

Background NLRP12 (NOD-like receptor family (NLR) pyrin domain containing 12) is an innate immune check-point in regulating type I IFNs expression. Since NLRP12 may participate in the pathogenesis of ...

Background To compare disease manifestations and outcomes of juvenile-onset SLE (jSLE) and adult-onset SLE (aSLE) patients using a nested case control study of patients in a Singapore cohort. Methods ...

Vaccination prevents infectious diseases by inducing/enhancing protective immunity, potentially translating into a lower rate of invasive infections and hospital admissions. Patients with autoimmune ...

Background Litifilimab is a humanized IgG1 monoclonal antibody targeting BDCA2, a receptor predominantly expressed on plasmacytoid dendritic cells (pDCs). In Part A of the Phase 2 LILAC study ...

Systemic lupus erythematosus (SLE) is associated with a wide variety of ocular manifestations. Some of these include uveitis, occlusive retinal vasculitis, (epi)scleritis and keratitis. Uveitis is an ...

Background Around 963 A.D., Bishop Eraclius (Liège, Belgium) wrote an affidavit stating, ‘I … was nearly taken to death by the disease called Lupus.’ On the seventh night of praying at Saint Martin’s ...

Malignancy risk in systemic lupus erythematosus (SLE) is about 15% higher than the general age-and-sex-matched population. Hematologic cancers, especially B-cell lymphomas, are about three-fold ...

Background This study aimed to investigate the clinical characteristics, outcomes, and risk factors of patients with a rare but fatal manifestation of systemic lupus erythematosus (SLE), diffusive ...