tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

In addition, some patent applications directed to the diagnosis or treatment taking note of mitochondrial tRNA have been filed. “1) A method for diagnosing type 2 diabetes by chemical modification of ...

Raghu R. Chivukula, MD, PhD, a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is the ...

Alltrna is the latest in a growing number of startups with plans to develop therapies based on transfer RNA (tRNA), a family of RNA molecules that play a vital role in building proteins. The Cambridge ...

David G. Longstaff, Ross C. Larue, Joseph E. Faust, Anirban Mahapatra, Liwen Zhang, Kari B. Green-Church, Joseph A. Krzycki Proceedings of the National Academy of ...

RNA-binding proteins (RBPs) are central regulators of post-transcriptional gene expression. They modulate key aspects of mRNA metabolism—such as splicing, ...