Carson Beck threw a single-game season-high four interceptions as No. 2 Miami lost in stunning fashion, 24-21, to Louisville.

Carson Beck's Heisman Trophy odds took a major hit Friday night after No. 2 Miami lost 24-21 to the unranked Louisville Cardinals.

Louisville intercepted four of Miami star Carson Beck's passes and the Cardinals got one of the most significant wins in their history by topping the No. 2 Hurricanes 24-21 on Friday night.

The Sporting News. Add The Sporting News as a Preferred Source by clicking here. Miller Moss threw for 248 yards and accounted for all three touchdowns as Louisville knocked off No. 2 Miami 24-21 in the biggest road win in school history.

The Cardinals stunned the Canes 24-21 at Hard Rock Stadium, giving both teams 5-1 records. Heisman Trophy favorite Carson Beck threw four interceptions. Louisville took a 14-0 lead in the first quarter and never trailed.

Louisville has pulled off a stunning victory against the second-ranked Miami Hurricanes, winning 24-21 on Friday night

The Louisville Cardinals will face the Miami Hurricanes in this college football matchup on Friday night at Hard Rock Stadium.

The No. 2 Miami Hurricanes (5-0, 1-0 ACC) host the Louisville Cardinals (4-1, 1-1 ACC) on Friday night at Hard Rock Stadium as they look to stay undefeated. Kickoff from Hard Rock Stadium is set for 7 p.