Single cell gene expression studies often rely on single-cell RNA sequencing (scRNA-seq) alone. While scRNA-seq reveals which genes are turned on, it does not capture protein expression or changes to ...

Conventional studies on stem cell fates are primarily focused on transcription factors, with the limited consideration for 3D ...

DNA methylation is a key epigenome component that helps dictate how genes are expressed, contributing to normal cell and tissue differentiation during development, as well as the process of biological ...

For decades, synthetic biologists have been developing gene circuits that can be transferred into cells for applications such as reprogramming a stem cell into a neuron or generating a protein that ...

A new tool greatly improves scientists' ability to identify and study proteins that regulate gene activity in cells, ...

Single-cell analyses revealed molecular profiles that can distinguish PTSD from depression, potentially leading to better drugs for this psychiatric disorder. To test this hypothesis, Girgenti and his ...

The cell and gene therapy industry has achieved breakthroughs once thought impossible, translating novel concepts into real therapeutic options for patients. The FDA has now approved 43 cell and gene ...

Scientists at City of Hope® have uncovered a gene called SMOC1 that plays a surprising role in the development of type 2 ...

Scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S., and ...