Endophilin A1 at postsynaptic sites promotes inhibitory postsynaptic organization through interaction with gephyrin to maintain E/I balance, which is essential for the suppression of epilepsy ...

One of the smallest protein structures ever determined using cryo-EM, GAT1 is fundamental to GABA neurotransmission and its structural determination is pivotal to developing therapies for a range of ...

The neurotransmitter gamma-aminobutyric acid (GABA) is widely distributed in the mammalian central nervous system, where it acts as a major mediator of synaptic inhibition. GABA also serves as a ...

In a groundbreaking study, a New York University Langone research team believes they have honed in on the brain pathways of a genetically determined repetitive motor behavior that is linked to autism.

A Georgetown University pharmacology and physiology professor gave an overview of “The World of GABA” in the annual Stephen and Mary Krop Lectureship in Pharmacology April 12. Tom Krop said the ...

Using a mouse model, researchers have discovered a new daily rhythm in a type of synapse that dampens brain activity. Known as inhibitory synapses, these neural connections are rebalanced so that we ...

How do people think, feel, remember, and move? These processes rely on synaptic transmission, where chemical signals are passed between nerve cells using molecular structures called vesicles.

A new type of brain cell, called a glutamatergic astrocyte, has been discovered. It could explain how a variety of neurodegenerative conditions, such as Parkinson’s, develop. Brain cells can largely ...

The brain is an almost inconceivably complex system of billions of neurons interlinked via trillions of connections that work to coordinate everything you do, think, and feel (Zimmer, 2011). This ...