See our expert college football prediction as Ole Miss and Oklahoma face off in Week 9 — who wins, why, and what to expect in this marquee matchup.

Ahead of Saturday's game, here's a look back at Lane Kiffin's thoughts on Ole Miss and OU being annual opponents under the new SEC schedule format.

But this powder-keg Rebels attack is a test that Oklahoma has yet to face — it has yet to deal with an opponent that ranks inside the top 35 in offensive efficiency. Lane Kiffin’s balanced and unpredictable scheme is averaging about 500 yards and is churning out explosive plays in the nation’s top 15.

These are some of the X-Factors for the No. 13-ranked Sooners’ first top 15 battle against the Rebels. When we say coaching, we don’t mean Xs and Os. Brent Venables and this staff have got that part covered.

The SEC's new schedule format pairs Oklahoma with Ole Miss as a permanent opponent, a decision that has surprised many. Fans, media personalities, and even Ole Miss coach Lane Kiffin have expressed confusion over the matchup due to a lack of history or geographical connection.

The Oregonian/OregonLive sports staff returns with its picks for Week 9 of the 2025 college football season. While Oregon State has a bye this week, the No. 6 Oregon Ducks will host the Wisconsin Badgers at Autzen Stadium on Saturday afternoon.

This article was originally published on www.si.com/college/oklahoma as Oklahoma has Opportunity Against an Ole Miss Defense That's Struggled This Season.